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PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is related to silent chromatin. PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic areas induces transcriptional repression. EZH1 mediates methylation on histone H3 lysine 27 and enhances EZH2 in sustaining stem cell identification and executing pluripotency. There are a variety of different methods to administer the Lysine.
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